Journal article
Plasma concentration of Propionibacterium acnes antibodies and prostate cancer risk: Results from an Australian population-based case-control study
G Severi, BA Shannon, HN Hoang, L Baglietto, DR English, JL Hopper, J Pedersen, MC Southey, R Sinclair, RJ Cohen, GG Giles
British Journal of Cancer | Published : 2010
Abstract
Background:Recent studies in prostatic tissue suggest that Propionibacterium acnes (P. acnes), a bacterium associated with acne that normally lives on the skin, is the most prevalent bacterium in the prostate and in men with benign prostatic hyperplasia. Its prevalence is higher in samples from patients subsequently diagnosed with prostate cancer. The aim of our study was to test whether circulating levels of P. acnes antibodies are associated with prostate cancer risk and tumour characteristics using plasma samples from a population-based case-control study.Methods:We measured plasma concentration of P. acnes antibodies for 809 cases and 584 controls using a recently developed ELISA assay. ..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
We thank the study participants, and the many urologists, nurses, and histopathologists who kindly facilitated the recruitment and collection of patient information and pathologist reports. We thank Shang-Chih (Sun) Chen for his excellent work in performing the ELISA tests. This study was supported by infrastructure from the Cancer Council Victoria, and grants from the National Health and Medical Research Council of Australia (no. 450104, no. 504700, and no. 504702), the Tattersall's, The Whitten Foundation, and the Prostate Cancer Foundation of Australia. The study was approved by the Ethics Review Committee of the Cancer Council of Victoria (reference no. HREC 9500).